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Sildenafil

Sildenafil is a medication that belongs to a group of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It is known by the trade name Viagra.

Here are the characteristics of sildenafil

Mechanism of action

• Sildenafil works by blocking the enzyme phosphodiesterase type 5 (PDE5), which breaks down cyclic guanosine monophosphate (cGMP).

  During sexual stimulation, the release of nitric oxide (NO) in the penile tissues increases cGMP levels, causing relaxation of the smooth muscles of the blood vessels and increased blood flow to the penis.

• This allows an erection to be achieved and maintained.

Indications

• Sildenafil is primarily used to treat erectile dysfunction (erectile dysfunction) in men.
• It may also be prescribed for the treatment of arterial hypertension in the form of Revatio.

Onset of action

• Sildenafil has a rapid onset of action, usually beginning to act about 30 minutes after taking it, but in some individuals it may take up to 1 hour.

Duration of action

• The effects of sildenafil usually last 4 to 5 hours, which is the length of time it takes to achieve and maintain an erection.

Dosage

• The usual starting dose of sildenafil is 50 mg, which may be increased or decreased according to individual response and needs.
• The dose should be taken approximately 30 minutes to 1 hour before planned sexual activity.

Side effects

• Common side effects of sildenafil include headache, facial flushing, indigestion (e.g., nausea, diarrhea), vision changes (e.g., blurred vision, changes in color vision), increased blood pressure, and rarely hearing loss or changes in hearing.

Contraindications

• Sildenafil should not be taken with nitrates (e.g., nitroglycerin) because of a possible severe drop in blood pressure.

  It is contraindicated in patients with severe heart problems, recent myocardial infarction or stroke.